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KMID : 0043320090320101433
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Archives of Pharmacal Research
2009 Volume.32 No. 10 p.1433 ~ p.1439
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The Effect of Curculigoside on the Expression of Matrix Metalloproteinase- 1 in Cultured Human Skin Fibroblasts
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Woo Eun-Rhan
Lee Song-Yi
Kim Mi-Ran
Choi Hong-Seok
Moon Hyung-In
Chung Jin-Ho
Lee Dong-Gun
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Abstract
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The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-β-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.
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KEYWORD
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Curculigo orchioides G., Amaryllidaceae, Phenolic glycoside, Curculigoside, Cycloartane saponin, Matrix metalloproteinase-1, Type-1 procollagen
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